慢性中央血清性胆色素变异症的持续eplerenone治疗:从试点研究的长期结果
Giacomo Boscia1, Pasquale Viggiano1, Federica Marzulli1
1Department of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Clinical ophthalmology (Auckland, N.Z.)
|July 24, 2023
概括
在患有慢性中央血清性胆色素变异症 (cCSC) 的患者中,口服eplerenone (EPL) 治疗改善了视力,并减少了视网膜和冠状腺变化. 这些EPL的积极影响持续了长达四年.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 冠状腺疾病 冠状腺疾病
背景情况:
- 慢性中央血清性胆色素变异症 (cCSC) 是一种影响视网膜和胸膜的疾病.
- 帕奇科罗伊德的变化通常与cCSC有关.
- 长期治疗对形态功能结果的影响需要进一步研究.
研究的目的:
- 为了评估长期的视网膜和胸膜变化在cCSC pachychoroid眼睛治疗口服eplerenone (EPL).
- 评估持续EPL治疗对排泄性和非排泄性cCSC眼睛的形态功能影响.
主要方法:
- 一项试点研究涉及17名单边排泄性cCSC患者及其眼睛的同伴.
- 基线和6,12和48个月的随访评估对最佳校正的视敏度 (BCVA) 和光学连贯性断层扫描 (OCT) 参数进行评估.
- 使用OCT血管造影来评估choriocapillaris流动.
主要成果:
- 在48个月的时间里,排泄的cCSC眼睛显示出显著的BCVA改善和亚下液体和亚下胆道厚度 (SFCT) 的减少.
- 非排泄的同眼没有显著的BCVA变化,但显示SFCT和choriocapillaris流量缺陷减少.
- 治疗EPL的效果在一年内就显而易见,持续长达四年.
结论:
- 持续的口服EPL疗法在cCSC帕奇科罗伊德眼睛中显示出长期的形态功能益处.
- 对于cCSC的排泄性形式,EPL似乎有效,持续改善.
- 需要进一步的研究来证实这些初步发现.
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