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关于男性肥胖和性激素之间的关系的假定因果推断:双向的门德尔随机化研究
Bangbei Wan1,2, Ning Ma2, Zhi Zhou2
1Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan, China.
PeerJ
|July 24, 2023
概括
肥胖影响性激素水平:较高的体重指数 (BMI) 与较低的性激素结合型全球蛋白 (SHBG) 和生物可用的 (BioT) 有关,但较高的雌激素. 调节这些激素可能会减轻肥胖.
科学领域:
- 内分泌学和新陈代谢学
- 遗传学和基因组学 遗传学和基因组学
- 男人健康研究研究 男人健康研究
背景情况:
- 肥胖是一种常见的慢性疾病,也是对整体健康的重要风险因素.
- 体重指数 (BMI) 是评估肥胖的一个关键指标.
- 包括性激素在内的荷尔蒙失衡与肥胖的健康后果有关.
研究的目的:
- 研究身体质量指数 (BMI),性激素结合环球蛋白 (SHBG),生物可用 (BioT) 和雌激素水平之间的潜在因果关系.
- 探索欧洲成年男性这些关键生理标记之间的双向关系.
主要方法:
- 采用双向的门德尔随机化研究设计.
- 利用了来自欧洲15万多名成年人的全基因组关联研究 (GWAS) 数据.
- 与BMI,SHBG,BioT和雌醇相关的单核酸多态 (SNP) 作为仪器变量;反变量加权 (IVW) 方法是主要的.
主要成果:
- 体重指数升高与SHBG和BioT的降低以及雌激素的增加有遗传关联.
- 增加的SHBG与较低的BMI和BioT以及较高的雌激素有因果关系.
- 雌激醇对SHBG或BMI没有产生因果作用;生物疗法与较低的SHBG有关,但BMI没有.
结论:
- 在BMI,SHBG,BioT和雌激素之间存在一个复杂的因果关系网络.
- SHBG,BioT和雌醇可能会调解肥胖对男性健康的影响.
- 准SHBG,BioT和雌激素可能有助于管理男性与肥胖有关的健康问题.
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