针对结核病管理的临床药房服务:系统审查
D Iskandar1,2, F D A Suryanegara1,3, J F M van Boven4,5,6
1Unit of Global Health, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Frontiers in pharmacology
|July 24, 2023
概括
临床药房服务可以通过专注于遵守和安全来改善结核病的结果. 然而,需要更多的随机对照试验来证实这些效应并改善证据的一致性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 仍然是一个重大的全球卫生挑战.
- 有效管理结核病需要全面的患者护理策略.
- 临床药房服务在结核病管理中的作用尚未完全阐明.
研究的目的:
- 系统地审查结核病护理中临床药房服务的内容和潜在影响.
- 描述结核病管理中与临床药房服务相关的干预措施和结果.
主要方法:
- 按照PRISMA指南搜索了多个数据库 (PubMed,Embase,Cochrane,Scopus,Web of Science) 进行了搜索.
- 提取了研究特征和结果,使用药剂师干预表征工具的描述元素.
- 包括10项涉及1168名患者的研究,包括各种研究设计 (队列,病例控制,准实验,横截面).
主要成果:
- 临床药房干预侧重于药物遵守 (50%),安全 (40%) 和患者教育 (30%).
- 经常应用的干预措施包括药物信息/咨询 (80%) 和药物不良反应监测 (50%).
- 治疗成功率从72%到93%不等,治愈率和其他结果 (如唾液转换和生活质量) 的改善,尽管证据质量受到研究设计的限制.
结论:
- 临床药房服务显示出改善结核病结果的潜力,包括药物坚持和治疗成功.
- 由于缺乏高质量的随机对照试验,目前的证据有限且不一致.
- 建议使用标准化结果分类进行进一步的研究,以加强证据基础.
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