持续的术后疼痛的机制和管理
Alice M Fuller1, Sabah Bharde1, Shafaq Sikandar1
1William Harvey Research Institute, Charterhouse Square, Queen Mary University of London, London, United Kingdom.
Frontiers in pain research (Lausanne, Switzerland)
|July 24, 2023
概括
持续的术后疼痛 (PPP) 影响10%-50%的患者,急性和慢性疼痛之间的联系不清楚. 了解风险因素和机制是制定这种常见疾病的预防策略的关键.
科学领域:
- 疼痛医学 医学 疼痛医学
- 外科手术的结果
- 神经科学是一个神经科学.
背景情况:
- 持续的术后疼痛 (PPP) 影响10%-50%的患者,尽管现代手术技术.
- 手术后从急性疼痛转变为慢性疼痛的过程尚不清楚.
- 目前的疼痛管理通常依赖于阿片类药物,造成成和容忍等风险.
研究的目的:
- 审查PPP发展的潜在机制.
- 为了确定PPP的风险因素,如手术前的焦虑和严重的急性疼痛.
- 探索预防或早期干预的机会.
主要方法:
- 审查临床前模型和关于PPP的现有文献.
- 神经生物学和神经免疫路径的分析.
- 检查风险因素和疼痛管理策略.
主要成果:
- PPP发育受到边缘敏感化和中央神经可塑性等因素的影响.
- 神经免疫轴在感知信号传递中发挥着作用.
- 手术前的焦虑和急性疼痛持续时间是潜在的危险因素.
结论:
- 对PPP机制的进一步研究对于有效的预防至关重要.
- 针对特定的途径可能提供新的治疗策略.
- 更好地了解风险因素可以指导早期干预.
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