关于THC-O-酸盐的社交媒体讨论内容分析
Daniel J Kruger1, Karahmet Amila2,3, Sydney M Kaplan2,3
1Institute for Social Research, University of Michigan, Ann Arbor, MI.
Cannabis (Albuquerque, N.M.)
|July 24, 2023
概括
对THC-O-乙酸盐 (THCO) 的研究很少. 在线讨论揭示了用户体验,安全问题,如凯气体风险和潜在的迷幻效应,指导未来对这种流行的半合成大麻素的科学调查.
科学领域:
- 大麻素科学 大麻素科学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 消费者和监管机构对半合成大麻素越来越感兴趣.
- 缺乏关于THC-O-乙 (THCO) 等新型大麻素的科学研究.
- 在线论坛作为识别研究缺口的来源.
研究的目的:
- 调查THC-O-乙 (THCO) 的社交媒体论坛上讨论的主题和问题.
- 确定有关THCO的新出现的研究问题和用户关注点.
- 在未来对半合成大麻素的系统研究中提供信息.
主要方法:
- 来自THCO子reddit (2021年6月至11月) 的Reddit评论的定性内容分析.
- 由五名编码员和一个监督员组成的团队进行主题编码,以确定主要和次要主题.
- 代编码过程,以建立和确认主题.
主要成果:
- 确定了THCO的主要研究领域:产品成分的变化,用户体验,与其他大麻素的比较,潜在的迷幻效应,不良事件和减少危害.
- 突出了用户安全问题,包括在加热时释放凯气体的风险.
- 观察到加热吸入是最常见的注射方法,尽管存在安全问题.
结论:
- 在线讨论为用户的观点和THCO周围的新兴问题提供了宝贵的见解.
- 需要进行系统的研究,以解决产品的安全性,有效性和THCO的用户体验.
- 这些发现强调了对新型半合成大麻素的监管指导和公共卫生信息的需要.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
322
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
322
α-Halogenation of Carboxylic Acid Derivatives: Overview
3.4K
Unlike aldehydes and ketones, carboxylic acids do not readily participate in α halogenation reactions via enols or enolate intermediates. However, α-halogenated acids are obtained through other methods. One of the approaches is the Hell–Volhard–Zelinsky (HVZ) reaction, wherein the carboxylic acid is treated with halogen in the presence of PBr3. It involves the conversion of acid to acid halide, which exists in equilibrium with its enol form. The enol attacks the...
3.4K
Acid Halides to Esters: Alcoholysis
3.0K
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
3.0K
Organic Compounds
51.6K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
51.6K
NMR and Mass Spectroscopy of Carboxylic Acids
4.0K
In ¹H NMR spectroscopy, acidic protons (–COOH) of carboxylic acids are highly deshielded and absorb far downfield, at around 9–12 ppm. The chemical shift value depends on the concentration and solvent used.
While α protons of carboxylic acids absorb at 2–2.5 ppm, β protons absorb further upfield.
Carboxylic acids are easily identified by dissolving them in deuterium oxide, which results in a rapid exchange of the acidic protons with deuterium. This leads to the...
While α protons of carboxylic acids absorb at 2–2.5 ppm, β protons absorb further upfield.
Carboxylic acids are easily identified by dissolving them in deuterium oxide, which results in a rapid exchange of the acidic protons with deuterium. This leads to the...
4.0K
Aromatic Hydrocarbon Anions: Structural Overview
2.8K
Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous...
Due to the absence of continuous...
2.8K


