血液学和生物化学参数在入院时作为中度至重度COVID-19患者死亡率的预测指标
Danis Pertiwi1, Maritsatun Nisa2, Andina Putri Aulia1
1Department of Clinical Pathology of Faculty of Medicine, Universitas Islam Sultan Agung.
Ethiopian journal of health sciences
|July 24, 2023
概括
高C反应蛋白 (CRP) 水平是中度至重度COVID-19患者死亡率的最强预测因素. 其他因素,如白细胞和血小板数量也表明风险,强调早期诊断和流行病期间的资源管理.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 关键护理医学 关键护理医学
背景情况:
- 由于COVID-19的流行,需要有效地分配资源和及时诊断.
- 在严重的COVID-19病例中确定死亡率的关键预测因素对于患者管理至关重要.
研究的目的:
- 确定中度至重度COVID-19患者死亡率的最重要的预测因素.
- 评估各种血液学参数作为潜在的死亡率预测指标.
主要方法:
- 对253名中度至重度的COVID-19患者进行了回顾性队列研究.
- 血液学参数的分析,包括白细胞计数,中性细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),C反应蛋白 (CRP) 和D-二次体.
- 接收器操作特征 (ROC) 曲线分析以确定切断点和用于预测器识别的后勤回归.
主要成果:
- 与幸存者相比,未幸存者显示出明显更高的白细胞计数,NLR,C反应蛋白 (CRP) 和D-二次体水平.
- 不幸存者血小板数和绝对淋巴细胞数 (ALC) 显著降低.
- CRP水平≥8.41 mg/L准确预测死亡率 (98.1%的灵敏度,72.0%的特异性).
结论:
- 白细胞计数增加,血小板计数减少,高NLR,高CRP和高D-二次体与COVID-19患者的死亡风险增加有关.
- 在这个患者队列中,C-反应蛋白 (CRP) 成为死亡率最主要的预测因素.
- 这些发现强调了监测特定生物标志物的重要性,以便对严重的COVID-19的风险分层和管理.
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