相关实验视频
Updated: Jul 22, 2025
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
15.9K
关于从泰国丝和越南丝中制定微/纳米颗粒药物输送系统的差异:一个关键的比较
Ngoc Yen Nguyen1, Thi Ngoc Phuong Nguyen2, Nguyen Ngoc Huyen3
1Faculty of Chemical Engineering, College of Engineering, Can Tho University, Can Tho 900000, Viet Nam.
Heliyon
|July 24, 2023
概括
泰国和越南丝纤维素 (SF) 具有独特的结构性质,影响微/纳米粒子形成. 与泰国丝纤维素相比,越南丝纤维素产生的颗粒较大,吸毒和稳定性较低.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 丝纤维素 (SF) 是一种天然聚合物,其特性因丝虫的来源和种植方式而异.
- 了解这些变异对于优化SF应用至关重要,特别是在生物材料和药物输送方面.
研究的目的:
- 为了比较泰国丝纤维素 (SFT) 和越南丝纤维素 (SFV) 的特性.
- 评估它们形成微/纳米粒子的能力,并评估药物捕获效率和生物稳定性.
主要方法:
- 从SFT和SFV中提取和制造微/纳米粒子,使用海水淡化和凝结.
- 使用各种技术分析氨基酸组成,结构性质 (链组成,结晶性).
- 评估颗粒大小,药物 (安福特里辛B) 捕获效率,血液毒性和生物稳定性.
主要成果:
- SFT和SFV的氨基酸组成相似.
- 与SFV相比,SFT结构显示较少的重链,更多的轻链和P-25糖蛋白,以及较低的结晶度.
- 基于SFV的颗粒较大 (~1700nm vs. ~150nm),与基于SFT的颗粒相比,药物捕获效率较低 (64.3% vs. 79.3%),血液毒性更高,生物稳定性降低.
结论:
- 在SFT和SFV之间存在显著的结构差异,影响了微/纳米粒子特性.
- 这些发现为为特定应用选择适当的丝纤维素来源提供了洞察力,以最大限度地提高性能和有效性.
相关概念视频
01:16Drug Delivery: Overview
326
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
326
01:22Drug Delivery: Miscellaneous Routes
384
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
384