探索老年人下垂体手术中的内分泌学陷
Shinichiro Teramoto1,2, Shigeyuki Tahara1, Izumi Fukuda3
1Department of Neurological Surgery, Nippon Medical School, Tokyo 113-8603, Japan.
Heliyon
|July 24, 2023
概括
老年患者的内透视透视手术显示了甲状腺功能上的差异. 晚年老年患者需要使用TRH测试对甲状腺刺激激素分泌能力的具体评估.
科学领域:
- 神经外科 神经外科
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 透视透视形手术 (ETSS) 在老年人中越来越常见.
- 在老年人中,下垂体手术带来了独特的内分泌学挑战.
- 这项研究专门研究了老年患者群体中的这些挑战.
研究的目的:
- 为了比较早期与晚年老年患者的内分泌学结果,这些患者接受了针对非功能性垂体腺瘤 (NFPA) 的ETSS.
- 确定在老年人手术后评估前垂体功能的潜在陷.
主要方法:
- 对99名接受ETSS的NFPA的老年患者 (≥65岁) 的回顾性分析.
- 患者被分为早期 (65-74岁) 和晚期 (≥75岁) 的老年人群.
- 基线特征和前垂体功能的比较,包括手术前和手术后的甲状腺激素释放激素 (TRH) 测试.
主要成果:
- 在早期和晚年老年人群之间观察到甲状腺刺激激素 (TSH) 反应的显著差异.
- 在早期老年患者中,手术前的自由三甲状腺素 (T3) 水平与TSH反应相关.
- 在晚年老年患者中,手术前的自由T3水平明显较低,不论TSH反应如何.
结论:
- 早期患有NFPA的老年患者可能具有正常的TSH分泌能力,如果手术前自由T3水平正常.
- 晚年老年患者的TSH分泌能力需要使用TRH测试进行仔细评估,因为T3水平发生了变化.
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