纳米颗粒方法用于氨酸-氨酸系统
Sajini D Hettiarachchi1, Young M Kwon1, Yadollah Omidi1
1Department of Pharmaceutical Sciences, Barry and Judy College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USA.
Heliyon
|July 24, 2023
概括
纳米颗粒药物递送系统提供了一个有前途的解决方案,以克服当前的氨酸-血管素系统 (RAS) 抑制剂的局限性. 这些纳米级系统增强药物疗效,减少治疗RAS相关疾病的毒性.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
背景情况:
- 氨酸-动脉素系统 (RAS) 在全身高血压,心力衰竭,脏疾病和神经退行性疾病中发挥着关键作用.
- 激活RAS可以加剧炎症和纤维化,导致疾病的进展.
- 目前的RAS抑制药物面临诸多挑战,包括血脑屏障的穿透性较差,生物可用性低,半衰期短.
研究的目的:
- 审查纳米粒子介导药物递送系统 (DDS) 作为潜在的替代方案,以克服传统RAS抑制剂的局限性.
- 总结各种纳米粒子的物理和化学特性,用于与RAS相关的应用.
- 详细阐述纳米级DDS在管理RAS相关疾病中的潜在临床应用.
主要方法:
- 对纳米粒子DDS和它们在向氨酸 - 血管新生素系统中的应用现有文献的审查.
- 对纳米粒子特征的分析,如尺寸,水分散性,循环半衰期和生物相容性.
- 检查不同类型的纳米粒子,包括在RAS相关研究中使用的奇托,聚合物和纳米纤维.
主要成果:
- 纳米粒子DDS表现出独特的特征,如更小的尺寸 (1-100纳米),增强的水分散性,延长的循环和生物相容性.
- 纳米级DDS可能会降低药物剂量频率和急性毒性,同时改善治疗结果.
- 在与高血压,心血管疾病和COVID-19相关的研究中,各种纳米颗粒显示出有前途,所有这些都涉及RAS.
结论:
- 纳米粒子介导的DDS代表了针对RAS向疗法的重大进步,解决了传统药物的局限性.
- 纳米颗粒的独特特性为治疗一系列与RAS相关的疾病提供了增强的疗效和安全性.
- 进一步研究纳米颗粒的物理和化学特性对于优化它们在RAS疾病临床应用中的使用至关重要.
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