磁性驱动的玻璃眼疏通装置用于在植入后调节眼内压力
Inês C F Pereira1,2, Ralph J S van Mechelen3, Hans M Wyss1,2
1Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands.
Microsystems & nanoengineering
|July 24, 2023
概括
这项研究引入了一种新的微型玻璃眼植入物,配备可调节的磁性微膜. 这种设备允许对眼内压力 (IOP) 进行非侵入性控制,防止像低血压这样的并发症.
科学领域:
- 眼科医生 眼科 眼科
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 眼内压升高 (IOP) 是青光眼的主要危险因素.
- 目前的玻璃眼排水装置是被动的,缺乏手术后的IOP控制,风险低血压.
- 非侵入性IOP管理对于预防青光眼的进展和并发症至关重要.
研究的目的:
- 为了开发一种新的,微型玻璃眼植入物,具有可调节的水力动力学阻力,用于非侵入性IOP控制.
- 为了证明磁性微对于调节植入物内的流体通道的有效性.
- 提供安全的,最少的侵入性外科手术解决方案,用于治疗青光眼.
主要方法:
- 微型植入物的制造使用聚乙烯-块-异布-块-乙烯 (SIBS) 和秒激光加工的玻璃模具.
- 一个磁性微门与一个由SIBS与铁微粒制成的微笔形插头的集成.
- 在体外和体外微流体实验以测试门功能和水力动力学阻力.
主要成果:
- 磁性微成功控制了流体通道,通过外部磁铁打开或关闭它们.
- 在关闭时,微提供了足够的水力动力阻力,以防止低血压.
- 门在一段时间内表现出可重复和稳定的功能.
结论:
- 开发的微型玻璃眼植入物使得水力动力学抵抗的可重复的,非侵入性的调整成为可能.
- 这种新的设备提供了一个有前途的,安全的,并对玻璃眼外科手术进行最小入侵的选择.
- 植入物有助于术后IOP控制,减轻与低血压相关的风险.
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