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一个患有埃索诺菲尔粒状多炎的病例,同时涉及中枢神经系统和外周神经系统

Anusha Challa¹, Sai Sirisha¹, Harsh Khandelia²

¹Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, India.

Oxford medical case reports

|July 24, 2023

概括

乙酸性粒状多炎 (EGPA) 是一种罕见的血管炎,可以影响中枢神经系统和外周神经系统. 这一案例突出显示了晚发EGPA的严重神经并发症,包括自主功能障碍.

科学领域:

神经学神经学
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

埃索诺菲尔粒状多炎 (EGPA) 是一种罕见的抗中性粒细胞体抗体 (ANCA) 相关的血管炎.
EGPA通常涉及呼吸道,并可能导致eosinophilia的全身并发症.
在EGPA中,中枢神经系统 (CNS) 的参与比外周神经系统 (PNS) 的参与少.

研究的目的:

报告一种罕见的晚发性EGPA病例,其中中枢神经系统和神经系统同时受到影响.
突出EGPA中可能出现严重的神经症状,包括自主功能障碍.
强调早期诊断和EGPA管理的重要性,以预防并发症.

主要方法:

一个患有晚发性EGPA的病人的病例报告.
详细的临床表现,神经学检查和诊断工作.
关于EGPA与神经系统参与的文献综述.

主要成果:

患者出现了晚期发作的喘,随后是急性心脏病发作和脱髓性多基核神经病.
神经系统的进展包括气囊和严重的自律障碍,这表明中枢神经系统和神经系统同时受到影响.
神经病变对标准免疫抑制和皮质类固醇治疗具有耐药性.

结论:

即使在晚期发病的情况下,EGPA也可能出现严重且同时涉及中枢神经系统和外周神经系统.
在EGPA中自主功能障碍可能表明多系统参与,并预测严重的并发症.
及时诊断和全面管理对于改善EGPA患者的神经症状的治疗结果至关重要.

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