开发数字双胞胎用于预测和控制批量冷却结晶过程中的超和
Ryan Leeming1, Tariq Mahmud1, Kevin J Roberts1
1School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, U.K.
概括
模型预测控制 (MPC) 使用数字双胞胎精确管理批量结晶中的超和. 这种在物理结晶器上验证的方法,为精细化学生产和未来的晶体大小优化提供了精确的控制.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 过程控制 过程控制
- 结晶技术 结晶技术 结晶技术
背景情况:
- 通过批量结晶,精确控制超和对于精细化学品生产至关重要,因为它决定了晶体尺寸分布和产品特性.
- 传统的实证控制方法资源密集;基于机械模型的控制提供了更有效的替代方案.
研究的目的:
- 开发和验证一种模型预测控制 (MPC) 策略,用于批量结晶中的超和控制.
- 创建一个结晶过程的数字双胞胎,用于in silico控制战略的开发和测试.
主要方法:
- 使用gPROMS.中的六胺乙醇系统的实验数据开发了一种一维人口平衡模型 (PBM).
- 该PBM与控制软件 (PharmaMV) 集成,以创建用于训练MPC块的数字双胞胎.
- 在物理结晶器上实施了MPC策略,使用现场ATR-FTIR光谱仪进行实时度测量.
主要成果:
- 数字双胞胎在0.012-0.036设定点范围内表现出极好的超和控制性能.
- 物理实现显示,由于未建模的传热干扰,比模拟显示的不稳定性略高.
- 实现的超和控制对于实际应用来说是准确和精确的.
结论:
- 与数字双胞胎集成的模型预测控制,为批量结晶中的超和控制提供了有效的策略.
- 开发的方法是准确和精确的,足以用于工业精细化学品的生产.
- 未来的工作可以将MPC策略适用于高级控制目标,例如直接操纵晶体大小.
相关概念视频
Recrystallization: Solid–Solution Equilibria
1.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.1K
Crystal Growth: Principles of Crystallization
2.1K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
2.1K
Precipitation Processes
490
The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
490
Solution Equilibrium and Saturation
18.7K
Imagine adding a small amount of sugar to a glass of water, stirring until all the sugar has dissolved, and then adding a bit more. You can repeat this process until the sugar concentration of the solution reaches its natural limit, a limit determined primarily by the relative strengths of the solute-solute, solute-solvent, and solvent-solvent attractive forces. You can be certain that you have reached this limit because, no matter how long you stir the solution, undissolved sugar remains. The...
18.7K


