甲状腺皮层网络与酒精使用障碍的注意力减弱的关联
Niklaus Denier1,2, Leila M Soravia1,2,3, Franz Moggi1,2
1Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Frontiers in psychiatry
|July 24, 2023
概括
酒精使用障碍 (AUD) 中的正念缺陷与中脊柱体核 (MD-TN) 和其网络中的大脑变化有关. 这些结构和功能变化可能解释AUD患者的注意力受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 在饮酒障碍 (AUD) 中,正念与减少饮酒量有关.
- 在AUD中正念的神经生物学基础仍然不清楚.
- 本研究的重点是甲状腺皮层系统,特别是中背甲状腺核 (MD-TN) 以及它与默认模式网络 (DMN) 和突出网络 (SN) 的连接.
研究的目的:
- 在AUD患者中研究甲状腺皮层系统中的结构和功能性大脑变化.
- 检查MD-TN,DMN和SN在AUD中观察到的正念缺陷中的作用.
- 假设在AUD中减少了正念和损害了甲状腺皮层连接.
主要方法:
- 招募了45名戒断AUD患者和20名健康对照 (HC).
- 获得结构和休息状态功能性MRI扫描.
- 通过使用多变量统计和基于种子的分析,分析了正念水平,乳头体积,MD-TN网络中心性和功能连接 (FC).
主要成果:
- 与HC相比,AUD患者表现出较低的正念水平,降低了thalamic和MD-TN体积,并在MD-TN和前 cingulum/insula之间降低了FC.
- 在AUD中较低的正念与MD-TN中的结构和功能缺陷相关.
- 在AUD患者中观察到左MD-TN的网络中心性降低.
结论:
- 涉及MD-TN和DMN/SN的网络中的结构和功能变化与AUD中的注意力受损有关.
- 这些发现表明AUD中正念缺陷的神经生物学基础.
- 针对MD-TN和相关网络可能为AUD提供治疗潜力.
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