新生儿,婴儿和未满五岁的新生儿,婴儿和未满五岁的婴儿在发达国家常规给予的疫苗剂量及其与死亡率的关联
Neil Z Miller1, Gary S Goldman2
1Medical Research, Institute of Medical and Scientific Inquiry, Santa Fe, USA.
Cureus
|July 24, 2023
概括
发达国家婴儿疫苗接种率较高,婴儿死亡率增加. 这项研究发现,新生儿,婴儿和五岁以下儿童的疫苗剂量数量与死亡率之间存在正相关性.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 儿科 儿科 儿科
背景情况:
- 2011年之前的研究表明,发达国家的婴儿疫苗剂量数量与婴儿死亡率之间存在正相关性.
- 使用2019年的数据重新评估了这一趋势,证实了与线性回归分析的关联.
研究的目的:
- 研究各国所需的幼儿疫苗剂量数量与新生儿,婴儿和五岁以下儿童死亡率之间的关系.
- 通过分析不同年龄组和疫苗接种计划的死亡率来扩大以前的发现.
主要方法:
- 使用线性回归分析的生态研究设计.
- 分析了2019年和2021年的数据,以查看疫苗剂量与死亡率 (新生儿,婴儿,五岁以下) 之间的相关性.
- 对那些需要零,一个或两个新生儿疫苗剂量的国家进行了分层分析和ANOVA,并进行了后期的Tukey-Kramer测试.
主要成果:
- 在2021年新生儿疫苗剂量数量与新生儿,婴儿和五岁以下儿童死亡率之间发现了统计学上显著的正相关性.
- 需要两剂新生儿疫苗接种的国家的婴儿死亡率与需要零剂量的国家相比显著更高 (1.28例死亡/1000例活产差异).
- 在使用2019年和2021年数据的18项统计分析中,有17项证实了所需疫苗剂量数量与婴儿死亡率之间的积极关联.
结论:
- 发达国家的死亡率 (新生儿,婴儿,五岁以下) 与早期儿童疫苗剂量数量之间存在统计学上显著的正相关性.
- 研究结果表明,可能需要对当前的疫苗接种计划进行进一步调查,以确保它们实现预期的公共卫生目标.
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