蛋白质设计的AI模型正在推动抗体工程
Michael Chungyoun1, Jeffrey J Gray1,2
1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21287, USA.
Current opinion in biomedical engineering
|July 24, 2023
概括
深度学习和蛋白质结构预测正在彻底改变治疗抗体工程. 这些进展使得能够设计出具有增强结合性和类似药物的抗体,以改善治疗方法.
科学领域:
- 生物技术是生物技术.
- 计算生物学 计算生物学
- 免疫学 免疫学 免疫学
背景情况:
- 治疗性抗体工程旨在开发具有精确目标结合和最佳药物特性的抗体.
- 深度学习 (DL) 方法通过整合现有知识和实验数据来增强抗体生成.
- 预测蛋白质结构的进展,包括抗体和抗原,对于这个领域至关重要.
研究的目的:
- 审查基于深度学习的蛋白质结构预测和设计在抗体治疗中的整合.
- 突出基于结构的生成模型在抗体工程中的影响.
主要方法:
- 利用深度学习的进步来预测蛋白质结构.
- 使用抗体和抗原的预测结构.
- 应用基于结构的生成模型用于抗体设计.
主要成果:
- 强大的基于结构的生成模型的出现,用于抗体设计.
- 通过深度学习指导改进的抗体生成方法.
结论:
- 基于深度学习的结构预测和设计正在改变抗体疗法.
- DL和结构生物学之间的协同作用加速了基于抗体的新药的开发.
更多相关视频
10:17Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
Published on: January 14, 2020
7.8K
08:15Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Published on: September 28, 2018
11.0K
相关概念视频
01:10Antibody Structure
60.4K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.4K
01:31Hybridoma Technology
15.0K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
15.0K