关于压力和心血管风险的神经生物学机制的试点研究
J Douglas Bremner1,2,3, Marina Piccinelli2, Ernest V Garcia2
1Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
概括
心理压力会影响大脑和心脏,增加冠心病 (CHD) 的风险. 这项研究揭示了压力如何影响心脏病患者的大脑活动,炎症和心肌缺血.
科学领域:
- 心血管疾病研究研究
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 冠心病 (CHD) 是全球死亡的主要原因.
- 将心理压力与心血管疾病风险和死亡率的增加联系在一起的确切机制仍然不完全理解.
- 在应激反应中研究大脑-心轴对于理解心血管疾病的发病过程至关重要.
研究的目的:
- 阐明心理压力影响大脑和心脏的机制,从而增加心脏病风险.
- 评估脑活动,外周器官功能和心脏病患者在精神压力下的心脏事件之间的关系.
主要方法:
- 冠心病患者 (N=10) 在休息和精神压力期间接受心脏成像 (SPECT).
- 使用[18F]FDG的正子发射断层扫描 (PET) 用于评估大脑,心脏,骨髓,大动脉和脂肪组织中的葡萄糖吸收.
- 在患有和没有精神压力诱导心肌缺血的患者之间比较葡萄糖吸收模式.
主要成果:
- 患有压力诱导性缺血的患者表现出心脏,中间前额叶皮质和脂肪组织的葡萄糖吸收增加.
- 压力诱导的中部前额叶皮和杏仁核中的活动与脏活动相关.
- 中部前额皮层活动增加与心脏葡萄糖摄取量增加相关,表明心肌缺血.
结论:
- 大脑区域之间存在着重要的联系,这些区域调解了对压力的情绪反应,以及参与炎症和造血活动的外周器官.
- 这些发现突出了一个潜在的途径,通过这种途径,压力会导致心肌缺血和心脏病的不良结果.
- 了解这种大脑与心脏的联系为管理与压力有关的心血管风险提供了新的途径.
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