早期环境和微量营养素的可用性对发育表观遗传编程的影响:来自胎盘的教训
Rebecca Sainty1, Matt J Silver2, Andrew M Prentice3
1Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, United Kingdom.
Frontiers in cell and developmental biology
|July 24, 2023
概括
孕期暴露极大地影响DNA甲基化模式,影响终身健康. 胎盘,与其可变的甲基组,提供了一个有希望的窗口,这些表观遗传效应和相关的妊娠并发症.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 人类健康 人类健康 人类健康
背景情况:
- 基因甲基化是影响基因表达和基因组功能的关键表观遗传标记.
- 表观遗传模式是在发育早期建立的,这使得孕前期至关重要.
- 怀孕期间的环境暴露可能对健康产生持久的影响,与DNA甲基化变化有关.
研究的目的:
- 突出围绕怀孕期暴露在塑造DNA甲基化中的关键作用.
- 确定胎盘作为一种关键组织,用于研究转移性形基因 (ME) 和环境影响.
- 为了将胎盘中的异常DNA甲基化与妊娠并发症和晚年疾病风险联系起来.
主要方法:
- 审查关于DNA甲基化,孕期暴露和健康的发育起源的现有文献.
- 专注于转移性基基 (ME) 和它们的可变性.
- 检查胎盘甲基组变异性及其与怀孕结果的关联.
主要成果:
- 孕期暴露,包括微量营养素,可以影响DNA甲基化.
- 胎盘表现出显著的个体间甲基组变异性,使其成为一个有价值的模型.
- 胎盘中的异常DNA甲基化与妊娠并发症,如子宫前和子宫内生长限制有关.
结论:
- 围绕受孕的窗口对于建立稳定的DNA甲基化模式至关重要,这将对终身健康产生影响.
- 胎盘是环境暴露的重要接口,反映了表观遗传修饰.
- 了解胎盘DNA甲基化是预测和潜在地减轻妊娠并发症和未来疾病风险的关键.
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