介质细胞干细胞疗法改善过早卵巢衰竭的卵巢功能:基于临床前研究的系统综述和元分析
Congcong Guo1, Yubo Ma2, Yanqiu Situ1
1Reproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Frontiers in endocrinology
|July 24, 2023
概括
介质干细胞 (MSC) 移植在动物模型中显示出治疗早产卵巢衰竭 (POF) 的前途. 这一元分析证实MSC可以通过调节激素和恢复生殖周期来改善卵巢功能.
科学领域:
- 生殖生物学 生殖生物学
- 干细胞疗法是一种干细胞疗法.
- 动物模型动物模型
背景情况:
- 过早的卵巢衰竭 (POF) 是一个重大挑战.
- 介质干细胞 (MSC) 在动物研究中显示出对POF治疗的潜力.
- 之前的研究缺乏足够的样本大小来得出最终的结论.
研究的目的:
- 在动物模型中系统地审查和元分析MSC移植在治疗POF中的疗效.
- 巩固关于MSCs对POF的治疗潜力的证据.
主要方法:
- 对37项涉及1079只动物的研究进行了系统审查和元分析.
- 根据PRISMA指南,搜索了七个数据库.
- 使用SYRCLE的偏差风险工具评估方法质量.
主要成果:
- MSC移植显著改善了雌激素 (E2) 水平和卵泡数量 (原始,初级,二级).
- 此外,MSC还调节了卵泡刺激激素 (FSH) 水平和其他卵巢标记物.
- 没有观察到FSH/LH比率,黄体或雌激周期的显著差异.
结论:
- 在POF的动物模型中,MSC移植显示了治疗效果.
- 这些效应与改善性周期调节和正常化血清激素水平有关.
- 在POF模型中,MSC显示出恢复卵巢功能的潜力.
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