在2型糖尿病中BMI和LDL胆固醇之间非线性关联中的性别差异
Kun Li1,2, Bin Cao1,2, Xiaojing Wang1,2
1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|July 24, 2023
概括
在2型糖尿病 (T2DM) 患者中,体重指数 (BMI) 显示男性的低密度脂蛋白胆固醇 (LDL-C) 与反转的U形关系. 这表明LDL-C与较瘦男性的BMI一起增加,但在肥胖男性中呈平原或下降.
科学领域:
- 代谢健康 代谢健康
- 心血管疾病风险因素 心血管疾病风险因素
- 糖尿病管理 糖尿病管理
背景情况:
- 之前的研究已经在一般人群中确定了身体质量指数 (BMI) 和低密度脂蛋白胆固醇 (LDL-C) 之间的线性联系.
- 由于样本大小的限制,对2型糖尿病患者 (T2DM) 这种关系的研究有限.
研究的目的:
- 调查BMI和LDL-C之间的非线性剂量反应关系,特别是在T2DM患者中.
- 探索基于性别的这种关系中的潜在差异.
主要方法:
- 利用通用添加模型 (GAMs) 来分析北京卢河医院2500名T2DM患者 (30-70岁) 的数据.
- 采用平滑线和细分回归来可视化和量化BMI和LDL-C之间的非线性关联,按性别分层.
主要成果:
- 在男性T2DM患者中观察到BMI和LDL-C之间的反转U形关联.
- 在男性中,LDL-C与BMI一起增加到26.08的断点,之后它倾向于平稳或下降.
- 在女性T2DM患者中,BMI和LDL-C之间没有发现显著的反转U形关联.
结论:
- 在男性T2DM患者中,BMI和LDL-C之间的关系是非线性的,呈现出反转的U形状.
- 这表明,虽然较高的BMI与较瘦男性的LDL-C增加有关,但在肥胖男性中,这种效应会减少或逆转.
- 在T2DM中,BMI-LDL-C关系在两性之间存在差异,男性表现出明显的非线性模式,而女性没有观察到这种模式.
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