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一个生物相容的MgAl-LDH支持Ru单原子纳米酶的原子化诱导的高内在活性,用于有效的激素清理

Bingqing Wang¹, Yingyan Fang¹, Xu Han¹

¹State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029, Beijing, P. R. China.

Angewandte Chemie (International ed. in English)

|July 24, 2023

概括

我们在MgAl层的双氧化物 (Ru1/LDH) 上开发了一种新型的单原子纳米酶 (SAE),具有优异的过氧化酶类活性. 这种先进的纳米酶有效地清除多个自由基,为生物应用提供了潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物化学生物化学

背景情况:

开发高效的纳米酶用于反应性基因清除是至关重要的,但受到传统纳米酶活性的限制.
与纳米粒子相比,单原子纳米酶 (SAE) 提供了增强的催化性能.

研究的目的:

开发一种新单原子纳米酶 (SAE),具有高催化活性,用于反应性激素清理.
调查新型SAE的催化机制和激素清除能力.

主要方法:

在MgAl层的双氧化物上合成单原子鲁纳米酶 (Ru1/LDH).
对过氧化酶类 (POD) 活性的评估和与Ru纳米集群 (NCs) 的比较.
密度函数理论 (DFT) 计算以阐明催化机制.
对多种自由基 (O2•−,•OH,NO•,DPPH•) 的清理能力的评估.

主要成果:

Ru1/LDH SAE表现出比Ru NC (20倍高) 和大多数报告的SAE显著更高的本质POD类活动.
DFT的计算显示,单个Ru位点上的H2O2分离通过异解途径的自由能量障碍较低.
Ru1/LDH SAE证明了超氧化离子基,基基,氧化基和DPPH基的优秀清理.

结论:

Ru1/LDH SAE具有卓越的过氧化酶类活性和广泛的自由基清除能力.
增强的活性归因于独特的电子结构和单个Ru位点的异质H2O2解离路径.
由于其高活性,生物安全性和可扩展性,Ru1/LDH SAE在生物免疫系统中显示出实际应用的希望.

关键词:

有层的双氧化.多种酶的多种酶.类似过氧化酶的在这里,我们可以说是鲁鲁鲁鲁.单原子纳米酶是一种单原子纳米酶.

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