青少年的疼痛史和实验压力疼痛反应:基于人口的出生队列的结果
Maria Brandão1,2, Makram Talih1,2,3, Sinead Holden4
1EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
European journal of pain (London, England)
|July 24, 2023
概括
青少年从小就有反复的肌肉骨疼痛史显示压力疼痛耐受性降低,这表明长期的疼痛有助于敏感化. 当前疼痛本身并不能显著改变这个年龄段的疼痛敏感性.
科学领域:
- 疼痛研究 疼痛研究
- 青少年健康 青少年健康
- 肌肉骨疾病 肌肉骨疾病
背景情况:
- 敏感的疼痛机制在肌肉骨疼痛中很常见,但缺乏儿科人口研究.
- 在有肌肉骨疼痛史的青少年中调查疼痛敏感性至关重要.
研究的目的:
- 评估有肌肉骨疼痛史的青少年是否表现出对实验压力刺激的反应增加.
- 在青少年中区分当前疼痛和长期疼痛史之间的疼痛敏感性.
主要方法:
- 利用了1496名青少年的数据 (第21代出生队列).
- 通过卢贝克疼痛问卷 (7,10,13岁) 评估疼痛史.
- 使用袖口压力算法测量疼痛检测/耐受性值,有条件疼痛调制 (CPM) 和疼痛时间总和 (TSP).
主要成果:
- 患有纵向肌肉骨疼痛的青少年 (疼痛在13岁和病史在7/10岁) 疼痛耐受性较低 (40.2比49.0kPa,p=0.02).
- 在纵向组中,没有发现疼痛检测,CPM或TSP的显著差异.
- 横截面疼痛定义 (仅当前疼痛) 在疼痛敏感度指标中没有显著差异.
结论:
- 长期的肌肉骨疼痛从童年开始,而不仅仅是当前的疼痛,可能会导致青少年的疼痛敏感性增加 (低压疼痛耐受性).
- 这些发现表明,慢性疼痛暴露在生命早期对发展疼痛敏感性的潜在作用.
相关概念视频
Population Growth
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.However, realistic environmental conditions limit the number of...
Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Normal Strain under Axial Loading
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
Introduction to Stress and Lifestyle
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...


