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狼性炎的抗C1q抗体患有球微血栓症的儿童

Pei Zhang¹, Xiao Yang¹, Xiang Fang¹

¹Department of Paediatrics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China.

Nephrology (Carlton, Vic.)

|July 24, 2023

概括

淋巴细胞微血栓症 (GMT) 在儿科狼性炎 (LN) 中很常见. 抗补剂1q (a-C1q) 和抗β2-糖蛋白I (a-β2GP1) 抗体的较高水平与这些儿童的GMT和较差的结果有关.

科学领域:

儿科脏病学儿科脏病学
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

淋巴细胞微血栓症 (GMT) 是儿科狼性炎 (LN) 中常见的血管病变.
了解导致GMT的免疫因素对于改善患者的治疗结果至关重要.
抗β2-糖蛋白I (a-β2GP1) 和抗补剂1q (a-C1q) 抗体与自身免疫性疾病有关.

研究的目的:

研究LN儿童血清a-β2GP1和a-C1q抗体之间的关联.
探索这些抗体对儿科LN的GMT有所贡献的潜在机制.
为了将抗体水平与临床,病理和预后因素相关联.

主要方法:

一组由191名通过活检诊断出LN的儿童组成的队列被分析.
患者被分为有GMT和没有GMT的组.
临床数据,实验室结果,病理和预后在各组之间进行了比较,重点是a-β2GP1和a-C1q抗体水平.

主要成果:

在儿童LN患者中的27.23%中存在GMT.
患有GMT的患者表现出较低的C3,血红蛋白和eGFR,但较高的血清肌素,蛋白尿,红细胞,NAG,RBP,a-C1q,a-β2GP1,SLEDAI和AI得分.
在GMT组中,a-C1q和a-β2GP1的阳性比例显著高于GMT组,a-C1q与疾病活性和严重程度正相关.

结论:

患有GMT的儿科LN患者出现更严重的疾病和较差的结局.
血清a-C1q水平与a-β2GP1具有积极的相关性,这表明a-β2GP1在GMT病变发生过程中的作用.
这些发现表明,a-β2GP1可能有助于儿童LN的GMT形成,可能是通过补充经典通路激活.

关键词:

抗β2-葡萄糖蛋白 I 抗体.抗补 1q 抗体抗补 1q 抗体孩子们的孩子们的孩子们的孩子们.质细胞微血栓形成狼性炎是一种神经炎症.脏活检脏活检

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