与COVID-19相关的血栓性微血管病变
Esra Karabag Yilmaz1, Memnune Nur Cebi2, Iremnaz Karahan2
1Department of Paediatric Nephrology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Nephrology (Carlton, Vic.)
|July 24, 2023
概括
感染COVID-19可能导致血栓性微血管病变 (TMA),这是影响血管的罕见疾病. 在儿科病例中,eculizumab治疗显示出有前途,这表明在选定的患者中对补充系统激活有潜在的益处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血栓性微血管病变 (TMA) 很少在COVID-19中报告.
- 了解COVID-19对TMA的影响对于患者管理至关重要.
研究的目的:
- 报告与COVID-19相关的两个儿科TMA病例.
- 评估eculizumab在治疗COVID-19相关的TMA中的疗效.
主要方法:
- 两名患有SARS-CoV-2感染和TMA的儿科患者的病例报告.
- 实验室调查包括PCR,血液学,凝血和补充分析.
- 在一个患者中使用eculizumab治疗.
主要成果:
- 两位患者均出现了微血管病变性血液溶解性贫血,血小板缩和急性损伤.
- 没有发现TMA的其他原因.
- 埃奎利祖马布治疗导致一个患有持续血液溶解和无尿症的患者的积极结果.
结论:
- COVID-19感染是TMA的一个潜在原因.
- 对于特定的COVID-19相关的TMA病例,尤其是具有补体系统激活的病例,eculizumab可能是有益的治疗选择.
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