在滴滴抑制期间的功能性连接预测,在图雷特综合征儿童的行为治疗后,语音滴滴的减少
Simon Morand-Beaulieu1,2, Michael J Crowley1, Heidi Grantz1
1Department of Psychology, McGill University, Montreal, QC, Canada.
Psychological medicine
|July 24, 2023
概括
在基线时滴滴抑制期间的大脑连接预测,在接受综合行为干预滴滴治疗 (CBIT) 的儿童中,语音滴滴严重程度降低. 这表明自愿性滴滴控制和图雷特综合征 (TS) 的CBIT之间有共同的机制.
科学领域:
- 神经科学是一个神经科学.
- 儿童心理学 儿童心理学
- 医疗成像医学成像
背景情况:
- 对的综合行为干预 (CBIT) 是对图雷特综合征 (TS) 的领先治疗方法.
- 通过CBIT降低的严重程度的确切机制尚不清楚.
- 之前的研究已经确定了一个功能性大脑网络,参与了TS儿童的滴滴抑制.
研究的目的:
- 调查在自愿性滴滴抑制期间的功能性大脑连接是否与接受CBIT的TS儿童的治疗结果有关.
- 探索自愿性滴滴抑制和滴滴行为疗法之间潜在的共享神经机制.
主要方法:
- 一项随机对照试验将CBIT与32名患有TS的儿童 (8-13岁) 的常规治疗进行比较.
- 电脑电图 (EEG) 在基线和终点时记录了滴滴抑制.
- 来源重建的EEG连接分析以评估功能连接.
主要成果:
- 从基线到终点,从基线到终点没有观察到抑制期间功能连接的显著变化.
- 在滴滴抑制期间的基线功能连接预测了CBIT组的语音滴滴严重性降低.
- 右上额头环和直角环的连接是关键预测因素.
结论:
- 在抑制期间的基线功能连接是CBIT声声严重程度降低的重要预测因素.
- 这些发现表明,自愿性滴滴抑制和图雷特综合征的CBIT之间的神经机制的重叠.
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