从童年到成年期中期的社会孤立:与大脑年龄的老化是否存在关联?
Roy Lay-Yee1, Ahmad R Hariri2, Annchen R Knodt2
1Centre of Methods and Policy Application in the Social Sciences, and School of Social Sciences, Faculty of Arts, University of Auckland, Auckland, New Zealand.
Psychological medicine
|July 24, 2023
概括
整个生命中的社会孤立与成年期中期的大脑年龄的老化有关. 防止社会孤立,特别是在成年期,可能有助于减缓大脑衰老和改善健康结果.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 通过结构性MRI估计的大脑年龄较大,与健康状况不佳相关.
- 社会孤立会对健康产生负面影响,并可能加速大脑衰老.
- 社会隔离的生命周期轨迹及其对大脑衰老的影响需要进一步调查.
研究的目的:
- 为了检查从5岁到38岁的社会隔离轨迹和45岁的大脑年龄之间的联系.
- 为了确定在整个生命过程中不同的社会隔离模式是否会缓和大脑衰老.
主要方法:
- 利用新西兰出生队伍的基于小组的轨迹分析来定义社会隔离类型.
- 确定了四组:"从未隔离"",仅限成人"",仅限儿童"和"儿童-成人"隔离.
- 在45岁时使用结构性MRI评估大脑年龄差距 (brainAGE),调整共变量.
主要成果:
- 成年期中期的大脑年龄较大与特定的社会隔离轨迹有关.
- "只有成人"隔离组与"从未隔离"组相比,显示出与大脑年龄较大的显著关联.
- 在调整了家庭和儿童混器后,关联仍然存在.
结论:
- 研究结果表明,终身社会隔离与加速大脑衰老之间存在联系.
- 防止社会孤立,特别是在成年期,可能是缓解大脑衰老的策略.
- 需要进一步的研究来了解将社会孤立与大脑衰老联系在一起的机制.
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