IL-17F基因多态性及其血清水平与SARS-CoV-2感染的关联
Shimaa R Hendawy1, Heba Wagih Abdelwahab2, Mohammed A Hegazy1
1Mansoura University Faculty of Medicine, Egypt.
Thoracic research and practice
|July 24, 2023
概括
升高的17型白内素水平与增加的冠状病毒疾病严重程度相关. 然而,互白素17F基因变异不会影响COVID-19患者的疾病倾向或结果.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 遗传学 遗传学 是一个
背景情况:
- 冠状病毒疾病 (COVID-19) 严重程度与高细胞动力症有关,特别是17型白蛋白 (IL-17) 的升高水平.
- 了解COVID-19的免疫和炎症概况对于预测疾病结果至关重要.
研究的目的:
- 研究血清IL-17水平和IL-17F基因多态性与COVID-19的严重程度和结果之间的关联.
- 阐明IL-17在COVID-19感染期间炎症反应中的作用.
主要方法:
- 在90名COVID-19患者和30名健康对照中使用ELISA测量了血清IL-17水平.
- 实时PCR用于IL-17F单核酸多态基因定型.
- 根据世卫组织的标准,COVID-19患者被分为非严重,严重和关键组.
主要成果:
- 与健康对照组相比,COVID-19患者的血清IL-17水平显著提高 (P < .001).
- 血清IL-17水平与疾病严重程度有积极的相关性,在危急病例中明显升高,而在严重 (P = .03) 和非严重 (P = .02) 病例中则明显升高.
- 在IL-17F基因型和COVID-19易感或严重程度之间没有发现显著的关联.
结论:
- 升高的IL-17是一种与COVID-19严重程度增加相关的生物标志物.
- IL-17F基因多态性似乎没有在COVID-19的严重程度或易感性中发挥作用.
- 进一步研究IL-17在COVID-19病原发生中的作用是有必要的.
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