基于罗达胺衍生物的光染料用于生物成像和治疗:最近的进展,挑战和前景
Shuang Zeng1,2, Xiaosheng Liu2, Yves S Kafuti2
1State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China. lihd@dlut.edu.cn.
Chemical Society reviews
|July 24, 2023
概括
罗达胺染料,最初用于生物成像,现在被设计用于疾病诊断和治疗. 本综述探讨了它们的综合诊断和治疗应用,以获得更好的健康结果.
科学领域:
- 生物技术和生物医学工程 生物技术和生物医学工程
- 有机化学 有机化学
- 医疗诊断和治疗 医学诊断和治疗
背景情况:
- 罗达胺染料具有优良的光学特性,使其对生物成像和生物分子检测具有价值.
- 最近的进展集中在设计用于治疗应用的罗达胺衍生物,包括癌症和细菌感染.
- 将诊断和治疗功能集成到单个分子平台中,对于个性化医学至关重要.
研究的目的:
- 审查罗达胺染料从生物成像到治疗剂的历史发展.
- 系统地分析基于罗达胺的衍生物,用于联合生物成像,诊断和治疗.
- 讨论这些综合系统临床翻译的挑战和未来前景.
主要方法:
- 罗达胺染料开发和应用的文献综述.
- 对用于生物成像和疾病治疗的罗达胺衍生物进行系统分析.
- 讨论设计策略,挑战和临床翻译.
主要成果:
- 罗达胺染料已经从简单的光标记物演变为复杂的光剂.
- 许多罗达胺衍生物在可视化生物系统和治疗癌症等疾病方面都表现出有效性.
- 诊断和治疗能力的整合为新型疾病管理策略提供了一个有希望的途径.
结论:
- 罗达胺染料代表了开发综合诊断和治疗剂的多功能平台.
- 进一步的实践整合和临床翻译研究对于实现其全部潜力至关重要.
- 在临床实践中,基于罗达胺的治疗药物的未来前景非常重要.
相关概念视频
01:19Protein Dynamics in Living Cells
2.2K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.2K
01:29Two-Dimensional Microscopy in Microbiology
81
Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
81
01:12Immunofluorescence Microscopy
10.7K
A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.
10.7K