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在基因组基础上对VIM/IMP的流行病学分析 Carbapenemase-producing Enterobacter spp., 波兰

Radosław Izdebski, Marta Biedrzycka, Paweł Urbanowicz

Emerging infectious diseases

|July 24, 2023

概括

波兰的碳烯酶产生肠道细菌 (CPE) 由于Enterobacter hormaechei.的克隆传播而增加. 像In238和In916这样的特定整体子类型通过质粒和基因组岛屿促进了这种传播.

科学领域:

微生物学微生物学
遗传学是一个遗传学.
流行病学流行病学

背景情况:

生产碳酶的肠道细菌 (CPE) 是一个重大的全球健康威胁.
肠道细菌 spp. 进入细菌 spp. 越来越多地被认为是重要的CPE病原体.

研究的目的:

调查2006-2019年波兰VIM/IMP碳酶生成肠道细菌 (CPE) 的遗传基础和流行病学趋势.
确定CPE在波兰出现和传播的主要驱动因素.

主要方法:

934个非重复的CPE分离物的全基因组测序.
细菌血统,序列类型 (ST) 和携带碳烯酶基因的移动遗传元素的分析.
随着时间的推移,孤立分布和发病率的流行病学分析.

主要成果:

肠道细菌 spp. 进入细菌 spp. 约占排序的CPE分离物的40%.
肠杆菌hormaechei,特别是ST90,ST89和ST121的克隆传播是CPE发病率增加的主要驱动因素.
确定了三个主要的VIM编码整体子类型 (In238-like和In916-like),通过各种等离子体和基因组岛屿在多个Enterobacter STs中传播.

结论:

由移动遗传元素促进的特定Enterobacter hormaechei系的克隆扩张是波兰CPE发病率上升的一个主要因素.
了解碳烯酶基因的传播机制对于控制CPE爆发至关重要.

关键词:

埃尔·霍尔马切切伊 (E. Hormaechei) 是一个著名的作家.肠道细菌 (Enterobacter) 是一个细菌.进入细菌体中的细菌.波兰波兰波兰波兰 ST8989 是一个人.ST90 ST90 是一个人.VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM VIM Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim Vim V 抗微生物耐药性抗微生物耐药性细菌细菌细菌是一种细菌.

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