在住院的埃及儿科患者中评估 ceftriaxone 药理动力学
Mohamed W Eldougdoug1, Doaa M Youssef2, Amal S El-Shal3,4
1Department of Pharmacy Practice, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. mohammed0494@gmail.com.
European journal of pediatrics
|July 24, 2023
概括
这项针对重症儿童的研究发现,塞夫特里亚克松的药理动力学与功能有所不同. 建议在治疗期间监测肝酶和胆红素,以防止潜在的不良影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科 儿科 儿科
- 临床药房 临床药房
背景情况:
- 塞夫特里亚克松是治疗儿科感染的关键抗生素.
- 了解其在重症儿童中的药理动力学对于有效治疗至关重要.
- 之前的研究表明,对氏的药理动力学模型有所不同.
研究的目的:
- 评估在重症埃及儿童中塞夫特里亚克森的药理动力学.
- 评估功能对triaxone 清除和分布的影响.
- 监测药物的不良影响,特别是肝功能和胆红素水平.
主要方法:
- 在24名住院儿科患者 (2.5个月12岁) 中对氏的药理动力学分析.
- 血液样本用HPLC分析了总和自由塞夫triaxone 度.
- 用Phoenix Winnonlin软件将数据安装到一个单间模型中.
主要成果:
- 塞夫特里亚克森清除与功能相关 (eGFR).
- 降低功能会降低清除,而增强清除会增加清除.
- 观察到分布体积和自由分量的增加,特别是在低albuminemia.
- 总胆红素和肝酶 (ALT,AST) 的轻微增加被观察到.
结论:
- 标准的塞夫triaxone 治疗方案 (50-100 毫克/公斤) 通常为严重病的儿童提供足够的覆盖.
- 塞夫特里亚清除受到个体功能显著影响.
- 在治疗中监测总胆红素和肝酶是必不可少的,尤其是在长期治疗或在患有高胆固醇水平的患者中,因为可能存在胆固醇形成的风险.
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