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在患有急性肺栓塞的患者中,托洛因依赖的30天死亡率
Emilie Sonne-Holm1, Matilde Winther-Jensen2,3, Lia E Bang2
1Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark. Emilie.sonne-holm.01@regionh.dk.
Journal of thrombosis and thrombolysis
|July 24, 2023
概括
在肺栓塞 (PE) 患者中,较高的激素水平与30天死亡率的增加有关. 这种剂量反应关系有助于更好地分层风险和治疗PE.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 生物标志物 生物标志物
背景情况:
- 较高的托罗邦度与肺栓塞 (PE) 患者的死亡率较高有关.
- 在PE中,托罗邦水平和30天死亡率之间的确切剂量反应关系需要进一步研究.
研究的目的:
- 确定是否存在托罗邦度和肺栓塞患者30天死亡风险之间的剂量反应关系.
主要方法:
- 从丹麦国家登记册中,从2013-2018年期间首次PE住院的5,639名成年患者的队列被确定.
- 根据入院后1天内测量的托罗邦度,患者被分为五分之一.
- 使用累积死亡率曲线和考克斯回归模型评估了30天死亡风险.
主要成果:
- 超过58%的PE患者 (3,278) 血红素水平升高,年龄较大,并具有较高的并发症负担.
- 观察到一个明确的剂量反应:30天死亡率从最低的热素五分位数的1%增加到最高的15%.
- 考克斯回归证实,随着热素水平的上升,死亡风险显著增加 (五分位数的HR从1.09到8.09不等).
结论:
- 热素度与PE患者的30天死亡率密切相关.
- 这些发现支持使用热素水平来增强PE管理中的风险分层和治疗策略开发.
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