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肝蛋白质学分析显示,在Lactiplantibacillus plantarum - 经过氧化应激治疗的肉中减轻了内细胞网膜压力

Junmeng Yuan¹, Yu Liu¹, Fan Zhao¹

¹College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.

Journal of agricultural and food chemistry

|July 24, 2023

概括

乳植物菌植物P8益生菌减少肝脏的氧化应激和肉的内质网膜应激. 这项研究揭示了P8调节关键蛋白质和谷氨代谢,为肝脏健康提供了潜在的治疗策略.

科学领域:

动物科学动物科学
微生物学微生物学
生物化学生物化学

背景情况:

细胞内膜网膜 (ER) 的压力与氧化压力 (OS) 和肝损伤有关.
已知Lactiplantibacillus plantarum P8 (P8) 影响肉生殖系统和肠道微生物群,但其对肝脏ER压力的影响尚未探索.

研究的目的:

调查P8在减轻肉肝OS和ER压力的作用.
使用蛋白质组学阐明潜在的分子机制.

主要方法:

brojlers 受到德克萨米他 (DEX) 诱导的氧化应激.
进行P8治疗以评估其保护作用.
蛋白质组学分析确定了差异表达蛋白 (DEP).
通过RT-qPCR验证的蛋白质组学发现.

主要成果:

在DEX治疗的肉中,P8治疗显著降低了肝脏的OS和ER压力.
蛋白质组学揭示了DEP参与细胞对未折叠蛋白质的反应.
确定了关键的DEP (GGT5,TXNDC12,SRM),与OS和ER压力有关.
丰富分析突出显示了谷氨代谢途径.

结论:

在肉中,P8有效地减轻了肝脏的OS和ER压力.
该机制涉及GGT5,TXNDC12,SRM和谷氨代谢的调节.
P8为肉肝健康提供了一个有前途的益生菌干预措施.

关键词:

牛奶植物植物菌植物植物 (Lactiplantibacillus plantarum) 是一种植物.牛肉肝是什么意思牛肉肝细胞内膜网膜的压力应激氧化应激是一种氧化应激.蛋白质组学蛋白质组学

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