在伊朗的住院患者中出现了抗胆素的Acinetobacter baumannii克隆复合体2 (CC2)
Bahareh Hajihashemi1, Ali Abbasi2, Dariush Shokri3
11Department of Microbiology, Science and Research Branch, Islamic Azad University, Arak, Iran.
Acta microbiologica et immunologica Hungarica
|July 24, 2023
概括
这项研究在伊朗医院中发现了抗胆素的Acinetobacter baumannii. 多位序列类型化揭示了ST2作为主导克隆,出现了新的ST415,ST391和ST1077菌株.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 宝曼尼菌 (Acinetobacter baumannii) 是医院感染的重要原因之一.
- 抗生素耐药性的增加,特别是对胆固醇素的耐药性,构成了严重的公共卫生威胁.
研究的目的:
- 从伊朗的住院患者中分离出抗胆固醇素的Acinetobacter baumannii分子特征.
- 通过使用多局部序列类型 (MLST) 确定这些耐药菌株的遗传相关性.
主要方法:
- 收集临床样本并识别Acinetobacter baumannii的分离物.
- 抗生素敏感性测试,包括素的最小抑制度 (MIC).
- 使用帕斯图尔方案进行多位数序列类型化 (MLST).
主要成果:
- 在70个Acinetobacter baumannii分离物中,有7个呈现出对胆固醇素的耐药性.
- 所有抗胆固醇耐药的分离物也对所有其他测试的抗生素具有耐药性.
- MLST确定了五种序列类型 (ST):ST2 (占主导地位),ST78,ST1077,ST415和ST391. ST2,ST391和ST415属于克隆复合体2.
结论:
- 抗胆固醇的Acinetobacter baumannii ST2是伊朗临床环境中占主导地位的克隆.
- ST415,ST391和ST1077代表了伊朗的新发现.
- 加强监测和控制措施至关重要,以打击多药耐药的Acinetobacter baumannii的传播.
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