通过性别中立的HPV疫苗接种,建立有弹性的宫癌预防
Irene Man1, Damien Georges1, Rengaswamy Sankaranarayanan2
1International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention and Infections Branch, Lyon, France.
eLife
|July 24, 2023
概括
转向性别中立的HPV疫苗接种可以显著提高宫癌预防能力,防止计划中断. 这一战略改善了保护,并加速了朝着世界卫生组织的进展.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19大流行严重扰乱了全球人类乳头瘤病毒 (HPV) 疫苗接种计划.
- 宫癌预防策略很容易受到这样的程序中断的影响.
- 目前的HPV疫苗接种策略主要针对女孩,可能会限制广泛的影响和弹性.
研究的目的:
- 评估从仅针对女孩的 (GO) 转向性别中立 (GN) 的HPV疫苗接种策略的影响.
- 评估宫癌预防计划对疫苗接种中断的弹性.
- 确定GN疫苗接种在实现世界卫生组织的宫癌消除门方面的有效性.
主要方法:
- 利用基于代理的模型EpiMetHeos,与印度的流行病学数据进行校准.
- 模拟了一个5年中断场景,疫苗接种覆盖率不同 (60%和90%).
- 在中断和不中断条件下,GO和GN疫苗接种策略之间的结果比较.
主要成果:
- 转向GN疫苗接种增加了弹性,在5年中断期间,预防了每10万名女孩的子宫癌病例的2.8倍,覆盖率在60%以下,覆盖率在90%以下的病例是2.2倍.
- 基因菌疫苗接种显著降低了长期的年龄标准化宫癌发病率,低于世卫组织的消除值 (覆盖率为60%的每10万女性年中有2.8例,覆盖率为90%的2.4例).
- 相比之下,在60%覆盖率的GO疫苗接种导致发病率为每10万女性年中有4.7例,仍然高于门.
结论:
- 性别中立的HPV疫苗接种是预防子宫癌的更有弹性的策略,特别是在计划中断期间.
- 实施转基因疫苗接种加快了朝着世界卫生组织消除宫癌的目标的进展.
- 这些发现支持政策转向GN HPV疫苗接种计划,以提高公共卫生结果.
关键词:
在COVID-19大流行中,宫癌:子宫癌是一种癌症.流行病学流行病学性别中立的疫苗接种方式全球卫生健康全球卫生健康人类 人类 人类 人类 人类 人类 人类人类乳头瘤病毒 人类乳头瘤病毒恢复力 恢复力更多相关视频
12:34Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
19.2K
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.7K
相关概念视频
Cancer Vaccines
405
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
405
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Preventive Healthcare Services
1.1K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.1K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Disorders of the Female Reproductive System
410
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
410
Sexually Transmitted Infections
352
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
352
