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针对的多目标深度大脑刺激.

Andrew I Yang1, Faical Isbaine1, Abdulrahman Alwaki2

  • 1Departments of1Neurosurgery and.

Journal of neurosurgery
|July 24, 2023
PubMed
概括
此摘要是机器生成的。

多目标深度大脑刺激 (DBS) 为耐药性患者提供了一种安全和可行的方法,这些患者不适合标准治疗. 这种方法有望减少发作的频率,特别是在复杂的病例中.

关键词:
泰拉木斯前核的前核.中心中间的核核.深度大脑刺激 刺激大脑是一种.中背部核 中背部核.脉动性核的核亚体的细胞核.

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科学领域:

  • 神经外科 神经外科
  • 发病学 (Epileptology) 是一个专业的学科.
  • 神经调节是一种神经调节.

背景情况:

  • 深度大脑刺激 (DBS) 是一种正在发展中的耐火性的手术治疗方法.
  • 标准的DBS点包括前额/部的乳头前核 (ANT) 和泛性的中枢中核 (CM).
  • 患有复杂综合征的患者通常不符合这些标准目标的标准.

研究的目的:

  • 评估多目标DBS在复杂耐药性患者中的可行性,安全性和发作结果.
  • 介绍作者与DBS的经验,以多个不同的核心为目标,超越ANT和CM.
  • 为未来研究多目标DBS的长期疗效提供基础.

主要方法:

  • 一个单一中心的回顾性研究,涉及成年患有耐药性的患者.
  • 患者接受了DBS,针对2-3个不同的thalamic/subthalamic核,每半球植入两个电极.
  • 纳入标准包括多焦点性,多焦点性,扩散发作,后部发作或综合性普遍性和焦点性.

主要成果:

  • 8名患者接受了多目标DBS,没有出现手术并发症.
  • 随访时间超过6个月的5名患者显示,整体和/或发作频率减少了≥50%.
  • 两名患者经历过渡性不良刺激效应,通过编程调整进行管理.

结论:

  • 多目标DBS是管理复杂的程序上可行和安全的策略.
  • 这种方法可能会最大限度地提高患有挑战性症状的患者的治疗结果.
  • 需要进一步进行足够强大的研究来确认多目标DBS的长期疗效.