美国全国代表性样本中的尿和子宫内膜异位症患病率:来自NHANES 1999-2006年的结果
Mandy S Hall1, Nicole M Talge1, Kristen Upson1
1Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Human reproduction (Oxford, England)
|July 24, 2023
概括
暴露于有毒金属与更高的子宫内膜异位症患病率有关. 这项研究发现,在美国妇女的尿水平较高的情况下,子宫内膜异位症的风险增加.
科学领域:
- 环境健康 环境健康
- 妇科 妇科 妇科 妇科
- 毒理学 毒理学 毒理学
背景情况:
- 暴露很普遍,它具有雌激素性质.
- 之前对和子宫内膜异位症的研究显示了相互矛盾的结果.
- 子宫内膜异位症是一种具有显著发病率的疾病,其中雌激素起着关键作用.
研究的目的:
- 调查尿度与美国人口内宫内膜异位症患病率之间的关联.
- 为了确定长期暴露是否与子宫内膜异位症的风险增加有关.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (1999-2006) 的横截面研究.
- 分析了20-54岁的1647名女性的尿水平和自我报告的子宫内膜异位症诊断.
- 使用日志双项回归来计算调整后的流行率 (aPRs).
主要成果:
- 尿的高四分位数与子宫内膜异位症患病率的增加有关.
- 与最低四分位数 (aPR 2.0) 相比,的第二和第三四分位数的参与者显示子宫内膜异位症的患病率是子宫内膜异位症的两倍.
- 建议在最高四分位数 (aPR 1.6) 的患病率增加60%.
结论:
- 尿中的度与子宫内膜异位症的更高患病率有关.
- 研究结果表明,暴露可能会导致子宫内膜异位症的风险.
- 需要进一步的研究来证实这些联系,因为无处不在的暴露和子宫内膜异位症的发病率.
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