分子瘤板作为一种临床工具,用于将分子数据转换为现实世界患者护理
Andrea Vingiani1,2, Luca Agnelli1,3, Matteo Duca3
1Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
JCO precision oncology
|July 24, 2023
概括
分子瘤板 (MTB) 通过将下一代测序 (NGS) 数据与向治疗相匹配,促进精确瘤学. 现实世界的数据显示,更大的NGS面板可以改善可操作的目标检测,增强个性化癌症护理.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 下一代测序 (NGS) 正在改变瘤学,将重点从组织学转移到个性化治疗的分子标.
- 批准的癌症药物越来越依赖于特定的生物标志物,因此需要将分子数据集成到临床实践中的工具.
研究的目的:
- 评估分子瘤板 (MTB) 在实施精密瘤学的突变模型中的实用性.
- 通过多学科的团队方法,评估将下一代测序 (NGS) 数据与个性化治疗相匹配的有效性.
主要方法:
- 机构分子瘤委员会 (MTB) 每周通过电话会议召开会议,讨论高级/转移性固体瘤的分子数据和治疗方案.
- 从2020年5月至2021年10月期间的1,996名患者的分子数据的评估.
主要成果:
- 确定了超过1万种变异,其中43.2%被认为具有功能相关性 (致病性或可能致病性).
- 711名患者 (35.6%) 根据可行的变体被确定为可能符合针对性治疗的患者.
- 较大的NGS面板 (>50基因) 在识别可操作的目标方面比较小的面板 (≤50基因) 更有效.
结论:
- 分子瘤板 (MTB) 对于将NGS数据集成到临床实践中非常有价值,有助于精确瘤学.
- 现实世界的数据支持MTBs在将分子变化与针对性治疗相匹配的作用,以实现个性化癌症治疗.
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