外源性黑激素对双相情感障碍的睡眠和昼夜节律参数的影响,伴随着并发性延迟睡眠-清醒阶段障碍:一个动图研究
Francy Cruz-Sanabria1, Ugo Faraguna2, Miriam Violi3
1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, via Savi 10, 56126, Pisa, Italy.
Journal of psychiatric research
|July 24, 2023
概括
外源性黑激素 (exo-MEL) 改善了双极性障碍 (BD) 患者的睡眠模式,这些患者患有延迟睡眠-清醒阶段障碍 (DSWPD). 治疗延长了入睡时间,提高了睡眠效率和持续时间,这表明对BD睡眠障碍的潜在益处.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 经常与睡眠障碍和昼夜节律异常有关.
- 延迟睡眠-觉醒阶段障碍 (DSWPD) 是一种常见的昼夜节律障碍,可加剧 BD 患者的睡眠问题.
研究的目的:
- 为了评估外源性黑激素 (exo-MEL) 在改善睡眠和昼夜参数的疗效,在euthymic BD患者与并发性DSWPD.
- 为了评估个性化的exo-MEL治疗方案对时间型,睡眠开始和睡眠质量的影响.
主要方法:
- 一组由83名安乐死性BD患者组成的队列通过动图进行了时间型 (rMEQ),睡眠质量 (PSQI) 和昼夜参数的评估.
- 符合DSWPD标准的25名患者接受了2毫克的exo-MEL三个月,定时在基线睡眠开始前4小时.
- 睡眠参数在 (T0) 治疗前和 (T1) 治疗后使用威尔科克森签名等级测试进行了比较.
主要成果:
- 在完成治疗的19名患者中,降低的早晨 - 傍晚问卷 (rMEQ) 得分显著增加 (p=0.006),表明朝早转变.
- 睡眠开始时间 (SOT) 显著提升 (p=0.039),睡眠效率 (p=0.01) 和总睡眠时间 (p=0.04) 显著改善.
- 在DSWPD的BD患者中,exo-MEL治疗对自我报告的时间型,睡眠开始时间,睡眠效率和睡眠持续时间进行了积极的修改.
结论:
- 个性化外源性黑激素治疗显示,在患有并发性DSWPD的双相情感障碍患者改善睡眠模式方面具有潜在的有效性.
- 这些研究结果表明,exo-MEL可能是治疗睡眠障碍的可行的治疗方案,用于治疗这种患者群体的睡眠障碍.
- 需要进一步的随机对照试验来证实这些初步结果,因为研究的局限性,包括没有对照组和随机化.
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