在主要非心脏手术中使用德克萨米他的成本效益和长期结果
Marwan Bouras1, Amandine Clément1, Solène Schirr-Bonnans2
1Nantes Université́, CHU Nantes, Service d'Anesthésie Réanimation Chirurgicale, INSERM CIC 0004 Immunologie et Infectiologie, Nantes F-44093, France.
Journal of clinical anesthesia
|July 24, 2023
概括
手术后的德克萨米他在重大非心脏手术中没有证明具有成本效益. 虽然它略有降低了成本,但它具有成本效益的概率在不同的支付意愿值中仍然很低.
科学领域:
- 麻醉学 麻醉学
- 卫生经济学 卫生经济学
- 外科手术的结果
背景情况:
- 术后的德克萨米他正在研究在重大非心脏手术中降低发病率和死亡率.
- 帕克曼试验调查了德克萨米他的作用,而这项研究重点关注其成本效益.
研究的目的:
- 评估在接受重大非心脏手术的患者手术后给予德克萨米他的成本效益.
- 从健康支付人的角度评估经济影响,在12个月的时间内.
主要方法:
- 一项PACKMAN试验的辅助研究,涉及137名患者进行了12个月的随访.
- 随机双盲,安慰剂控制的设计比较德克萨梅他 (0.2毫克/公斤) 与安慰剂.
- 从卫生支付人的角度进行的成本效益分析.
主要成果:
- 术后使用德克萨米他导致1年后每名患者的成本降低了358.06欧元.
- 在共同的支付意愿值下,德克萨米他具有成本效益的概率很低 (12-22%).
- 12个月后的死亡率相似:德克萨米他组的13.2%,安慰剂组的16.1%.
结论:
- 这项研究没有证明术后德克萨米他在重大非心脏手术中的成本效益.
- 观察到的成本节约不足以确定在典型的支付意愿门时的成本效益.
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