职业压力和疲劳为基础的多基因负债在10年的随访期内:一项一般人口研究
Aino Saarinen1, Jarmo Hietala2, Leo-Pekka Lyytikäinen3
1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland.
Psychiatry research
|July 24, 2023
概括
患有精神分裂症和抑郁症 (PGL) 的高遗传风险的个体经历疲劳增加,特别是在工作压力下. 这种对疲劳的高度易感性甚至在没有被诊断出精神健康障碍的情况下仍然存在.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 职业健康 职业健康 职业健康
背景情况:
- 多基因风险评分 (PGL) 表明对复杂疾病的遗传倾向.
- 患有高PGL但没有确诊疾病的个体仍然可能出现亚临床症状.
- 工作压力是一个重要的职业压力因素,与不良健康结果有关.
研究的目的:
- 调查精神分裂症和严重抑郁症 (PGL) 的高多基因负载是否与疲劳和工作压力增加有关.
- 检查随着时间的推移,PGL和感知到的工作特征之间的关系.
- 为了确定高PGL的个体是否更容易在工作压力下疲.
主要方法:
- 利用了基于人口的年轻芬兰人研究 (n=928) 的数据.
- 使用多基因风险评分的累积得分来评估PGL,用于精神分裂症和抑郁症.
- 在24-49岁的参与者中,追踪了疲劳水平和感知的工作特征 (工作压力,需求,控制,满意度,社会支持) 在10年的随访期间,不包括那些患有诊断障碍的人.
主要成果:
- 高的PGL并没有预测对工作环境的看法不那么有利.
- 高的PGL预测了成年早期和中年期疲劳的更高轨迹.
- 高的PGL预测,随着工作压力增加,疲劳的增加会更大.
结论:
- 患有高PGL的个体表现出更容易体验疲劳的责任,特别是在成年早期和中年.
- 这种增加的疲劳风险在高职位压力的条件下被放大.
- 研究结果表明,基因倾向于主观的健康挑战,特别是在职业环境中,独立于诊断的疾病.
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