免疫反应对呼吸甲动态的影响
Daniela Polag1, Frank Keppler1,2
1Institute of Earth Sciences, Heidelberg University, Im Neuenheimer Feld 236, Germany.
Journal of breath research
|July 24, 2023
概括
呼吸甲 (CH4) 水平可能表明氧化应激和免疫反应. 监测呼吸中的CH4动态和同位素为体内诊断和个性化医学提供了潜力.
科学领域:
- 生物医学诊断 生物医学诊断
- 人类生理学 人类生理学
- 分析化学是一种分析化学.
背景情况:
- 呼吸中的甲 (CH4) 传统上与肠道微生物有关.
- 新出现的证据表明,通过氧化应激,细胞内源性产生CH4.
- 呼吸CH4变化可能表明氧化应激增加,影响诊断.
研究的目的:
- 调查与免疫反应相关的呼吸中的CH4动态.
- 评估感染,炎症和疫苗接种期间的CH4变化.
- 探索呼吸中CH4作为免疫状态的生物标志物.
主要方法:
- 在两名受试者两年内对呼吸CH4水平的纵向监测.
- 气相色谱与火焰电离检测用于CH4量化.
- 气色谱仪-燃烧同位素比重质谱仪用于CH4稳定碳同位素分析.
主要成果:
- 在免疫活性期间观察到的呼吸CH4水平的显著偏差.
- 个体CH4范围被超越,表明从健康状态的偏离.
- 通过同位素分析证实了疫苗诱导的CH4降解.
结论:
- 呼吸中CH4度和同位素成分可以作为生物标志物.
- 这些生物标志物可以评估特定的免疫反应和个体免疫状态.
- 呼吸监测CH4对体内诊断和个性化医学具有前景.
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