在儿童伤修复期间的药理学程序性应急管理:系统性审查
Annisa Siu, Nam-Anh Tran1, Samina Ali2
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario.
Pediatric emergency care
|July 24, 2023
概括
口服米达佐拉姆和口服胺有望减少儿童在伤修复过程中的程序性痛苦. 然而,由于研究方法和结果的多样性,需要更多的研究.
科学领域:
- 儿科急救医学 儿科急救医学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 在接受撕裂修复的儿童中,程序性困扰是常见的.
- 有效的药理学药剂对于管理这种痛苦至关重要.
- 目前关于比较有效性的证据需要进行系统的评估.
研究的目的:
- 系统地审查有关药理学药物的有效性在治疗儿童在撕裂修复过程中的程序性痛苦的文献.
- 为了比较在这种情况下使用的抗焦虑药,镇静剂和止痛药的疗效.
- 为了确定最佳的代理,并告知未来的研究方向.
主要方法:
- 在六个数据库中进行系统的文献搜索 (更新于2023年1月).
- 纳入儿童 (<15岁) 进行伤修复的随机或准随机试验.
- 使用各种应急尺度评估疗效,其次要结果包括疼痛,接受和满意度.
主要成果:
- 21项试验 (n=1621) 研究了米达佐拉姆,胺和氧化 (N2O).
- 在多项研究中,口服米达佐拉姆,口服胺和N2O与对照剂相比,显示出优越的减轻痛苦.
- 对比器和结果指标的异质性排除了元分析.
结论:
- 口服米达佐拉姆和口服胺似乎有利于减少程序性痛苦.
- 由于研究异质性和结果矛盾,研究结果需要谨慎解释.
- 绝对不能推一个最佳的药物;需要进一步的研究来标准化结果措施.
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