多普勒在败血性休克中发现了静脉拥堵:国际多中心前性队列研究 (Andromeda-VEXUS) 的协议
Ross Prager1, Eduardo Argaiz2,3, Michael Pratte4
1Division of Critical Care, Western University Schulich School of Medicine & Dentistry, London, Ontario, Canada rprag011@uottawa.ca.
BMJ open
|July 24, 2023
概括
这项研究研究了使用多普勒超声波的败血性休克患者的静脉拥堵. 增加静脉堵塞与急性损伤的更高风险有关,需要置换疗法或死亡.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生理学 血管生理学
背景情况:
- 静脉拥堵,以高静脉压力为特征,导致器官功能障碍和更糟糕的结果,特别是急性损伤 (AKI) 在危急病患者中.
- 多普勒超声波可以通过评估下腔静脉 (IVC),肝静脉 (HV),门静脉 (PV) 和内静脉 (IRV) 来测量静脉堵塞.
研究的目的:
- 量化多普勒鉴定静脉拥堵与替代疗法 (RRT) 或性休克患者死亡的复合结果之间的关联.
- 评估静脉堵塞在预测严重损伤和败血症休克死亡的预后价值.
主要方法:
- 一项预先规定的ANDROMEDA-SHOCK 2 (AS-2) 随机对照试验的副研究,招募至少350名满足4小时内败血症-3标准的成年患者.
- 在随机化后6-12小时进行IVC,HV,PV和IRV的多普勒超声波询问.
- 使用Cox比例危险模型评估的主要结果,以确定28天内RRT或死亡的危险,并对竞争性风险进行分分布危险.
主要成果:
- (结果尚未提供,因为这是研究设计摘要)
结论:
- (结论尚未提供,因为这是研究设计摘要)
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