恐惧学习后皮质激素升高会损害远程听觉记忆检索,并改变大脑网络连接
Niek Brosens1, Sylvie L Lesuis2, Ilse Bassie3
1Brain Plasticity Group, Swammerdam Institute for Life Sciences (SILS)-Cognitive and Systems Neuroscience (CNS), University of Amsterdam, Amsterdam 1098 XH, the Netherlands a.a.d.brosens@uva.nl h.krugers@uva.nl.
Learning & memory (Cold Spring Harbor, N.Y.)
|July 24, 2023
概括
在学习后给出的皮质 (CORT) 会损害小鼠的远程恐惧记忆检索. 这种压力激素会破坏大脑区域的连接,影响长期记忆回忆.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子生物学分子生物学
背景情况:
- 葡萄糖皮质类药物是记忆的关键调节剂,可以通过适应性或不适应性来影响行为.
- 虽然它们在近期记忆中的作用已知,但葡萄糖皮质醇对远程记忆的影响仍然不清楚.
研究的目的:
- 在学习远程恐惧记忆之后,研究皮质 (CORT) 管理的影响.
- 探索CORT对长期记忆巩固和检索的影响背后的神经机制.
主要方法:
- 小鼠接受了听觉恐惧调节,随后注射了2毫克/公斤的CORT.
- 远程记忆在28天后进行了评估.
- 通过c-Fos免疫组织化学测量神经元激活,并通过相关性矩阵分析大脑区域的协同激活.
主要成果:
- 接受CORT治疗的小鼠显示显著损害远程听觉记忆检索.
- 尽管大脑的净活动类似,但CORT改变了大脑区域之间的相关活动.
- 在接受CORT治疗的小鼠中,观察到侧面杏仁体,基底杏仁体和背部牙状之间连接性减少.
结论:
- 学习后的皮质激素给药会损害小鼠的远程恐惧记忆.
- 杏仁体和海马体内的网络连接中断可能是这种记忆障碍的基础.
- 了解这些途径可以了解压力对记忆和潜在治疗点的影响.
更多相关视频
08:08Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
Published on: June 18, 2014
27.1K
08:32Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
22.9K
相关概念视频
Role of Amygdala in Memory
288
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
288
Traumatic Memory
114
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
114
Functional Brain Systems: Limbic System
3.0K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.0K
