渐进性多焦点白细胞脑病变:发病,诊断工具和对治疗反应的潜在生物标志物
Finja Schweitzer1, Sarah Laurent1, Irene Cortese1
1From the Department of Neurology (F.S., S.L., G.R.F., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany; Experimental Immunotherapeutics Unit (I.C.), NIH, Bethesda, MD; Cognitive Neuroscience (G.R.F.), Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich; Institute of Virology (S.S.), National Reference Center for Papilloma- and Polyomaviruses, Faculty of Medicine, University Hospital Cologne; Department of Neurology (T.S.), Hannover Medical School; Institute of Neuropathology (I.M.), University Medical Center Göttingen; and Department of Neuroradiology (M.P.W.), Hannover Medical School, Germany.
冠状病毒多细胞病毒 (JCV) 可以在免疫功能低下的患者中引起渐进式多焦点白血脑病 (PML). 早期诊断和恢复细胞免疫力是管理这种严重的大脑感染和开发新疗法的关键.
科学领域:
- 神经病毒学 神经病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 在大多数成年人中,JC多瘤病毒 (JCV) 建立了潜在的感染,但在免疫受损的个体中可以重新激活.
- 渐进性多焦点白血脑病 (PML) 是一种严重的,通常是致命的,由JCV重新激活引起的脑部感染.
- 对于患有多发性硬化症等疾病的新型免疫抑制疗法治疗患者来说,PML越来越被认为是不良事件.
结论:
- 在了解PML病理生理学,宿主病毒遗传学和诊断方面的进展为最终的临床试验铺平了道路.
- 开发预防选择和治疗治疗JCV相关疾病是一个关键的未满足的需求.
- 新型免疫治疗方法为未来的PML治疗策略提供了希望.
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