在子宫内,阿片类药物对胎儿生长的影响
Samantha A Dickson1, David P Mazza2, Madison L Waddell1
1College of Medicine, Central Michigan University, Mount Pleasant, MI, USA.
概括
产前阿片类药物暴露与早期胎儿生长限制有关,特别是在骨发育方面,这在妊娠18-22周时明显. 这项研究发现,暴露胎儿的头周长和手臂长度显著减少.
科学领域:
- 产科 产科 产科 产科 产科
- 胎儿的发育 胎儿的发育
- 药理学 药理学是指药理学的学科.
背景情况:
- 产前阿片类药物使用与降低出生大小有关.
- 对于因产前阿片类药物暴露而受到早期生长限制的影响的时间和特定参数的了解有限.
研究的目的:
- 评估妊娠18-22周之间暴露于阿片类药物的胎儿的全球和特定生长缺陷.
- 评估产前阿片类药物暴露对胎儿生长参数在解剖学超声波期间的影响.
主要方法:
- 从学术产科实践回顾电子病历的回顾性审查.
- 与暴露于阿片类药物的孕妇 (n=41) 与未暴露于阿片类药物的对照组 (n=308) 的比较,允许使用烟草/大麻.
- 分析超声波测量结果,将其编码为妊娠年龄的百分位数,控制人口统计和病史差异.
主要成果:
- 暴露于阿片类药物的胎儿在控制混杂因素后显示出显著的生长缺陷.
- 观察到头周长,双直径和手臂长度的减少大于10个百分点.
- 内生长限制 (IUGR) 在暴露于阿片类药物的组中被诊断为5倍.
结论:
- 胎儿暴露于阿片类药物与早在妊娠18-22周就可检测到的骨生长缺陷有关.
- 研究结果表明,产前阿片类药物暴露可能特别影响骨生长,而不是整体体重或身体组成.
- 建议对更大的队列进行进一步的研究,以确认对股骨长度的影响,并探索骨健康和免疫功能.
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