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替代拼接:一个桥梁连接NAFLD和HCC

Kequan Xu¹, Tiangen Wu¹, Peng Xia¹

¹Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China; Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary and Pancreatic Diseases of Hubei Province, Hubei, PR China.

Trends in molecular medicine

|July 24, 2023

概括

非酒精性脂肪性肝病 (NAFLD) 是肝癌 (HCC) 的一个主要风险因素. 总结了NAFLD向HCC进展的替代拼接 (AS) 和表观遗传变化,以及治疗策略.

科学领域:

肝病学和分子生物学.
癌症研究癌症研究
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

非酒精性脂肪性肝病 (NAFLD) 越来越被认为是肝细胞癌 (HCC) 的重要危险因素.
了解推动从良性肝病发展为HCC的分子机制对于制定有效的预防和治疗策略至关重要.
替代拼接 (AS) 已成为肝脏疾病的致病和转化过程中的关键参与者.

研究的目的:

审查替代拼接 (AS) 在NAFLD向HCC进展中的作用.
探索表观遗传修饰对AS和NAFLD和HCC肝细胞命运的影响.
总结目前和潜在的NAFLD,HCC及其早期过渡阶段的治疗方法.

主要方法:

文献综述和现有关于NAFLD和HCC拼接因子,AS和表观遗传修饰的研究综合.
分析剪接因子活性和表观遗传变化的变化如何影响肝细胞命运.
对NAFLD,HCC和早期疾病进展相关的治疗策略和药物的汇编.

主要成果:

在NAFLD和HCC中观察到剪接因子活性和异常AS的变化.
表观遗传修饰,包括DNA甲基化,RNA甲基化,基因素修饰和蛋白质酸化,显著影响AS,并有助于肝细胞转化.
各种治疗干预措施对管理NAFLD,HCC和疾病进展的中间阶段显示出希望.

结论:

由表观遗传机制调节的替代拼接是NAFLD发展和进展到HCC的关键因素.
准拼接因子和表观遗传途径为肝癌预防和治疗提供了一个有希望的治疗途径.
对这些分子事件的全面理解对于开发有效的临床策略来对抗NAFLD相关的HCC至关重要.

关键词:

替代性拼接是一种替代性的拼接.表观遗传修饰是一种表观遗传修饰.肝细胞癌是肝细胞癌.非酒精性脂肪性肝病是非酒精性脂肪性肝病.这是一个拼接因子.

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