从SARS-CoV-2-阳性捐赠者的非肺固体器官移植到未感染的接受者
Jason Wade1, Kaitlyn M Petitpas2, Wasim Dar3
1Department of Surgery, Hartford Hospital, Hartford, Connecticut.
Transplantation proceedings
|July 24, 2023
概括
从SARS-CoV-2阳性捐赠者的非肺部器官移植到未感染的接受者中是安全的. 这项研究发现,在实体器官移植接受者中没有显著的SARS-CoV-2传播风险.
科学领域:
- 移植免疫学 移植免疫学
- 传染病的传播是传染病的传播.
- 病毒学 病毒学
背景情况:
- 有限证据表明,在固体器官移植中,SARS-CoV-2从捐赠者传播到接受者的风险有限.
- 初步观察表明,非肺固体器官可以安全地从SARS-CoV-2-阳性捐赠者移植.
研究的目的:
- 评估固体器官移植受体中SARS-CoV-2的捐赠者-接受者传播的安全性和风险.
- 评估非肺部固体器官移植的结果,从SARS-CoV-2-阳性捐赠者转变为SARS-CoV-2-阴性接受者.
主要方法:
- 从SARS-CoV-2-阳性捐赠者到SARS-CoV-2-阴性接受者进行固体器官移植 (脏,肝脏,心脏) 的临床结果的回顾性审查.
- 在2021年6月至2023年1月期间在一个移植中心收集的数据.
主要成果:
- 26个固体器官 (13个脏,8个肝脏,3个心脏,1个心脏-脏) 从23名SARS-CoV-2-阳性捐赠者移植给25名接受者.
- 两个接受者在移植后检测出SARS-CoV-2阳性,但没有其他并发症.
- 所有接受者都活着,具有出色的全移植功能,没有与SARS-CoV-2相关的不良事件.
结论:
- 从SARS-CoV-2-阳性捐赠者转移非肺部器官的固体器官移植到未感染的接受者是安全的程序.
- 传染SARS-CoV-2的风险很小,在接收者身上没有观察到显著的不良影响.
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