在单次或联合暴露于聚乙烯微塑料和的肝毒性中,铁灭菌的影响
Lixin Wang1, Xuan Zhang2, Man Xu1
1College of Environmental Science and Engineering, Hebei University of Science and Technology, Hebei Key Laboratory of Pollution Prevention Biotechnology, Shijiazhuang, 050018, China.
Environmental pollution (Barking, Essex : 1987)
|July 24, 2023
概括
聚烯微塑料 (PS-MPs) 和 (Cd) 诱导肝细胞中的细胞死亡途径铁亡. 对PS-MPs和Cd的联合暴露通过增加氧化应激增加了这种毒性.
科学领域:
- 环境毒理学环境毒理学
- 细胞生物学 细胞生物学
- 纳米毒理学研究
背景情况:
- 微塑料 (MP) 是全球发现的新兴环境污染物,包括在人类样本中.
- 重金属经常与MPs共存,引发了人们对其联合毒性的担忧.
- 微塑料和重金属的特定毒性影响,特别是它们的联合影响,仍然在很大程度上是未知的.
研究的目的:
- 研究聚烯微塑料 (PS-MPs) 和化 (CdCl2) 对肝细胞 (肝细胞) 的毒性影响.
- 为了确定PS-MPs和CdCl2是否诱导铁亡,一种特定类型的编程细胞死亡.
- 阐明 PS-MP 和 CdCl2.2 的单一和组合毒性背后的机制.
主要方法:
- 在体内和体外实验中使用肝细胞进行实验.
- 细胞与PS-MPs和CdCl2共同化,以评估组合效应.
- 分析了细胞死亡的机制,包括铁灭标志物 (脂质氧化,铁积累),反应性氧物种 (ROS) 生产和抗氧化活性.
- 评估了铁灭抑制剂 (N-乙-氨酸,deferoxamine,ferrostatin-1) 的作用.
主要成果:
- (Cd) 被PS-MPs吸收,改变了它们的生理化学特性.
- 无论是PS-MP还是CdCl2,都诱导了肝细胞中的铁;PS-MP显示出比单独CdCl2更强的效果.
- 对PS-MPs和CdCl2的联合暴露通过增加ROS产量和抑制抗氧化活性来协同增强铁灭菌.
- 铁素-1 (Fer-1) 是一种铁灭的抑制剂,通过提高GPX4和SLC7A11的调节,有效地保护肝细胞,增强抗氧化系统.
结论:
- 聚乙烯微塑料和诱导肝细胞铁,联合暴露加剧了毒性作用.
- 增强的毒性是由增加的氧化应激和抑制的抗氧化防御作用.
- 向铁亡途径,特别是像Fer-1这样的抑制剂,提供了针对微塑料和重金属共毒性的潜在治疗策略.
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