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基于纳米架构的癌症光热废除:一个系统的审查

Reza Malekzadeh¹, Tohid Mortezazadeh², Waleed K Abdulsahib³

¹Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Radiation Science Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.

Environmental research

|July 24, 2023

概括

光热疗法 (PTT) 使用纳米粒子将激光转化为热量,有效地破坏癌细胞. 表面修饰的纳米粒子增强了针对性交付和精确癌症治疗的治疗结果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

光热疗法 (PTT) 是一种创新的,非侵入性的癌症治疗方法.
PTT使用染色体吸收的近红外激光,在瘤组织内产生热量.
等离子纳米材料经常与激光照射相结合,以提高PTT的有效性.

研究的目的:

系统地审查关于纳米颗粒 (NP) 在光热疗法中用于癌症治疗的已发表研究.
确定影响PTT有效性的关键参数,并探索NP设计的进步.
要总结由PTT诱导的癌细胞死亡的机制.

主要方法:

在PubMed,Cochrane,Embase和Scopus数据库中进行了系统和全面的文献搜索.
研究集中在纳米粒子 (NP) 用于PTT被收集和分析.
研究了NP类型,大小,度,表面变化和暴露条件等关键参数.

主要成果:

黄金,银和铁NP是PTT中最常用的药物.
表面修饰的NP可促进选择性输送和受控的高温,提高PTT的效率.
这些NP增强了反应性氧物种的产生,并损害了DNA和线粒体等细胞组件,诱导了亡.

结论:

纳米粒子为增强癌症治疗中的光热疗法提供了巨大的潜力.
在NP合成的进步允许量身定制的属性 (形状,尺寸,涂层) 提高精度和特异性.
未来的研究可以专注于为多模式癌症治疗策略开发NP.

关键词:

癌症癌症癌症癌症激光照射辐射的激光照射.局部高热症局部高热症光敏化剂是一种光敏化剂.光热疗法是一种光热疗法.等离子体纳米粒子的使用.

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