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内微生物群:多发性骨髓瘤微环境中的隐秘参与者

Gengjun Zhu¹, Lifang Jin², Weizhang Shen²

¹Central Laboratory, The Second Hospital of Jilin University, Changchun, China.

Biochimica et biophysica acta. Reviews on cancer

|July 24, 2023

概括

该研究发现,肠道微生物群可能会导致多发性髓瘤 (MM) 的发展. 微生物失生症和受损的肠道屏障可能导致微生物群迁移到骨髓,影响MM的进展.

科学领域:

在瘤学瘤学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

多发性骨髓瘤 (MM) 是一种无法治愈的血液性恶性瘤.
已在瘤组织中检测到微生物群,但其在MM中的作用未得到充分研究.
内微生物群在MM病变发生中的作用仍然不太清楚.

研究的目的:

批判性地审查多发性骨髓瘤瘤发生和进展中的微生物群的文献.
提出关于瘤内微生物群在MM的起源和作用的假设.
讨论MM治疗的潜在微生物学策略.

主要方法:

关于微生物群和多发性髓瘤的最新研究的文献综述.
使用2bRAD-M测序检测MM患者骨髓中的微生物群.
分析肥胖,糖尿病,肠道疾病和MM之间的联系.

主要成果:

在多发性骨髓瘤患者的骨髓中确认了微生物群的存在.
建议微生物失生症和肠道屏障受损有助于MM.
假设微生物群从肠道迁移到骨髓的影响MM.

结论:

内微生物群可能在多发性骨髓瘤瘤发生和发育中发挥关键作用.
肠道微生物失调和肠道屏障受损是MM的潜在贡献者.
微生物群操纵策略为MM提供了潜在的治疗途径.

关键词:

我们的肠道微生物组.肠道恒常性肠道恒常性内微生物群内微生物群多发性骨髓瘤是一种多发性骨髓瘤.

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